In terms of other physical constants, in this case the elementary charge e, the Planck constant h, the speed of light c, the permittivity of free space (electric constant) εo, and the permeability of free space (magnetic constant) μo, we can relate α to these quantities.
The amazing thing about the fine structure constant is that any change in one of the fundamental constants will change α. A change of just 4% of the constant will not allow carbon to form, and hence no carbon-based life. An even larger change to α > 0.1 would mean that stellar fusion can't take place and therefore no warm planets, no liquid water, and again no life.
Fun note: the product of the permittivity of free space εo and the permeability of free space μo is the reciprocal of the speed of light squared.
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